We define the collinear factorization scheme, which absorbs only the collinear physics into the parton distribution functions. In order to isolate the collinear physics, we introduce a procedure to combine real and virtual corrections, canceling infrared singularities prior to integration. In the collinear scheme, the factorization scale \mu has a simple physical interpretation as a collinear cutoff. We present a method for choosing the factorization scale and apply it to the Drell-Yan process; we find \mu \approx Q/2, where Q is the vector-boson invariant mass. We show that, for a wide variety of collision energies and Q, the radiative corrections are small in the collinear scheme for this choice of factorization scale.